Moist Exposed Burn Therapy (MEBT) was Introduced Into medical practice since two decades In China. The concept of this therapy is to expose the wound to a physiological moist environment to enhance natural healing processes. whereby keratinocyte migration, angiogenesis, and interaction with growth factors are Iacnitated MEBO iMoist Exposed Burn Ointment) IS the ointment. which has been developed to fulfill the above criteria.
MEBO is of natural and herbal edible origin. It is composed of B·sitosterol 0.25% as the main active ingredient.
The base of the Ointment is composed of sesame oil and beeswax. in addition to that, MEBO includes In Its formula 18 amino acids. 4 major fatty acids, vitamins. and polysaccharides.
Mode of Action :
MEBO acts by:
1- Providing an optimum physiological moisture necessary for regeneration and repair.
2- Inducing an anti·inflammatory effect reducing thereby edema and erythema.
3- Creating an atmosphere unfavorable for bacterial and fungal colonization.
4- Isolating and protecting exposed and Injured nerve endings producing thereby an analgesic effect.
5- Providing local nutrition for wound bed cells.
6- Liquefying the necrotic tissue.
7- isolating and protecting the wound bed from environmental factors but at the same time maintaining drainage and gaseous exchange.
8- Reducing body fluids loss from damaged skin (burns).
9- Absorbing reSIdual heat in acute burn wounds.
10- Expediting epithelialization with exceptionally acceptable cosmesis.
MEBO has been used successfully in the treatment of the following wounds:
1- First-degree burns, where the pain relief and the fast healing are remarkable, e.g sunburn.
2- Second-degree bums. superficial and deep. If properly applied. no skin grafting IS needed and Regeneration takes place from hair follicles and glands in the dermis and sux: cutaneous tissue.
3- Third-degree bums, to isolate the wound, reduce pain, and expedite nonsurgical debridement of the necrotic tissue to prepare the wound for grafting.
4- Donor site. to decrease pain, control Infection, and expedite healing (average of 7 days has been reported),
5- Chronic wounds including bed ulcers, diabetic foot. and leg ulcers.
6- Post laser resurfacing, chemical peeling, and dermabrasion.
7- Surgical wounds including obstetrical wounds.
8- Wound of circumcision.
9- Mucous membrane wounds such as buccal ulcers.
10- Cracked heels and cracked nipples.
Method of Application :
a) First degree burns (Superficial burns)
MEBO should be applied as immediately as possible. A thin layer (about 1 mm thickness) should cover the burnt area. It is better to keep the wound exposed, but if there is a need, a light dressing can be used. Reapplication should be done 3 to 4 times daily If exposed or twice daily If closed.
b) Second-degree bums
A thin layer of MEBO should cover the burnt area and renewed 3 to 4 times daily. Before reapplication. the liquefied necrotic tissue and the residues of the old MEBO Should be wiped off gently. It is better to keep the wound exposed. but If there is a need. a light dressing can be used and a relatively thicker layer (about 3mm thickness) should be applied and renewed twice daily.
Second Phase. repair period
MEBO should be applied as before. but less frequently (2 – 3 times daily).
c) The third Phase: rehabilitation period
MEBO should be applied as before, but only once daily.
d) Third-degree burns
MEBO should be applied as mentioned before 10 liquefy the necrotic tissue. A thin layer should cover the burnt site and renewed 3 to 4 times daily.
2- Donor Site
A thin layer of MEBO should cover the donor site and renewed 3 to 4 times daily if exposed or twice daily if closed.
3- Leg Ulcers
A sterile gauze should be impregnated with MEBO and should fill the cavity of the ulcer. and renewed twice daily.
4- Surgical and Obstetrical Wounds
MEBO should cover the wound in a relatively thick layer (about 3mm) under a sterile dressing and renewed twice daily.
5- Cracked Nipples
A thin layer of MEBO should be applied to the nipple under a light pad. and renewed 3 to 4 times daily. MEBO is safe for the infant that nursing can proceed without any hazards.
Toxicity and Side Effects :
MEBO is of pure herbal edible origin. No side effects to the product have been reported so far. except for rare allergic reactions to sesame oil.
Precautions for the Drug :
MEBO ointment may change its physical appearance during storage. especially during hot seasons. but it does not lose its efficacy.